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Similarly, activation of reactive astrocytes can be inhibited by KD (185)

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Indeed, vasculogenic ED and CV disease (CVD) are considered as different manifestations of a common underlying vascular disorder [4]

In vitro studies performed in cultured endothelial progenitor cells (EPCs) showed that TMAO promoted cellular inflammation and increased oxidative stress ( The NF-B pathway plays a regulatory role in the expression of many AS-related pro-inflammatory genes (Tak and Firestein, 2001

Interestingly, metazoans as a group exhibit a Met auxotrophy [135], suggesting the ability to generate Hcy from Cys was lost roughly coincident with the metazoan transition, when single-celled aquatic heterotrophic protozoans gave rise to the first primitive multicellular aquatic heterotrophic animals