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Hemin acts as a potent inductor of HO-1, which promotes the healing process through the reduction of oxidative stress as is evident by the diminished level of lipid peroxidation, and elevated levels of various antioxidant defense mechanisms, including GSH, SOD, GPx, and catalase [55, 120]

Cells use NAD+ to get energy from fuel sources like glucose, amino acids, and fatty acids

10.1080/15548627.2017.1309485 56 KirklandJ

On the other hand, the role of the anti-inflammatory cytokine interleukin 10 (IL-10) in TJ regulation has been demonstrated in IL-10 knockout mice

Phenylalanine ammonia-lyase (PAL) can reverse depression-like behavior in the LPS model by balancing inflammatory and oxidative effects [134]