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Description

SIRT1 reverses senescence via enhancing autophagy and attenuates oxidative stress-induced apoptosis through promoting p53 degradation

Methylation of CDKN2A silences this cyclin-dependent kinase inhibitor, disrupting cell cycle regulation and enabling unchecked cellular growth ( C-MYC , which promotes increased proliferation, metabolic reprogramming, and evasion of apoptosis