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Time-dependent ROC analysis further substantiated the models predictive capacity within this validation cohort, yielding AUC values of 0.612, 0.584, and 0.569 for 1-, 3-, and 5-year survival, respectively (Figure S2C)

Am J Pharm Health Res 2017

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These CAFs-derived molecules, IGF1/2, CXCL12 and beta-hydroxybutyrate, increased ROS level after radiation, thereby enhancing protein phosphatases 2A activity, inhibiting mTOR activation, and increasing autophagy in cancer cells (121)

These receptors can also assemble inflammasome complexes, such as NLR family pyrin domain containing 3 (NLRP3), in coordination with absent in melanoma 2 (AIM2), resulting in the release of pro-inflammatory cytokinesincluding interleukin-1 (IL-1), IL-18, and TNF-and thereby amplifying neuroinflammation (Elinav et al., 2011