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doi: 10.5858/arpa.2018-0147-OA

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FIGURE 3 2.4 GPX4 Glutathione peroxidase 4 (GPX4) is a membrane-associated phospholipid hydroperoxidase and the only enzyme in the GPX family that directly reduces and destroys lipid hydroperoxides, GPX4 is characterized early and characterizes as the lipid peroxidation inhibitory protein PIP, mainly due to its unique ability ( 2 O 2 and small molecule hydroperoxides, it is also capable of reducing complex lipid compounds such as phospholipids, cholesterol and cholesterol lipid hydroperoxides

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This section will highlight several key ferroptosis targets, as illustrated in Fig

Peptide-based therapeutics have emerged as promising alternatives, offering high specificity, favorable safety profiles, and unique biological activities compared to traditional treatments