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In the development of new therapies, metabolomics has identified numerous therapeutic targets for aberrant metabolic pathways by systematically comparing the metabolic differences between cancer and surrounding tissues

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Levels naturally decline with age, stress, alcohol, and intense training

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FASEB J 33:1084410858 Huang Y, Zhou J, Wang S, Xiong J, Chen Y, Liu Y, Xiao T, Li Y, He T, Li Y et al (2020) Indoxyl sulfate induces intestinal barrier injury through IRF1-DRP1 axis-mediated mitophagy impairment

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ZM: Writing review & editing, Formal analysis, Data curation

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While the precise contribution of each pathway and the specific post-translational modifications on FOXO1 were beyond the scope of this study, it is plausible that KRAS-driven alterations in PI3K/AKT/mTOR, ERK and PKA signalling not only modulate FOXO1 functional state but also drive its mRNA levels through FOXO1 transcriptional autoregulation (Shen et al, 2014)

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