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Depending on the cellular and physiological milieu, TQ can undergo both enzymatic and non-enzymatic redox reactions to generate either pro-oxidants (semiquinone) or antioxidants (thymohydroquinone)

In recent years, extensive research (Figure 2) has shown that TMAO can activate the inflammasome NOD-like receptor protein 3 (Nlrp3) through different pathways to activate the inflammatory signal pathway, resulting in aggravation of oxidative stress and, in turn, of endothelial dysfunction

10.1016/j.redox.2020.101493 216 SunX.ZhaoD.LuF.PengS.YuM.LiuN.et al (2020d)