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Subsequent reporter assays supported this, showing decreased activity of CAV2 promoter upon PPAR overexpression in 293T cells, confirming that PPAR could inhibit the transcription of CAV2 in normal cells (Fig

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Moreover, the biliary secretion of NO species was significantly diminished in UDCA-infused transport mutant [ATPbinding cassette C2/multidrug resistanceassociated protein 2deficient] rats, and this finding was consistent with the involvement of the glutathione carrier ABCC2/Mrp2 in the canalicular transport of GSNO

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In more detail, enterolactone at 200 nM maintained or improved Trans-Epithelial Electrical Resistance (TEER) values in HCT-8 and Caco-2/RAW-264.7 coculture models, enhancing ZO-1 protein expression in HCT-8 cells under inflammatory conditions