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GST-pi is a phase II enzyme that catalyzes the reaction of the GSH thiolate to toxic electrophilic compounds, thus allowing highly reactive carcinogens or radicals to be eliminated by excretion machinery 54, 55

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Theanine has structural similarity to the neurotransmitters glutamine and gamma aminobutyric acid (GABA)

Another model for cerebral ischemia is cell ablation via bacterial nitroreductase catalysis of toxic metronidazole, under the control of a neuroendothelial cell-specific promoter, which can damage brain tissues

While these models are invaluable for understanding biological mechanisms and demonstrating proof-of-concept, results in animals do not always translate directly to humans