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One published analysis of tens of thousands of GLP-1-related Reddit posts found gastrointestinal complaints were the most commonly reported theme overall, consistent with the trial tolerability signals above

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Early-stage research suggests intranasal dihexa may achieve therapeutic CNS concentrations with minimal systemic exposure, potentially extending the effective half life at the target site (hippocampus) while reducing plasma half life

To determine the assay window for the FP assay, the TIN2-FAM probe was prepared as a 16-M stock in aqueous buffer and titrated from 0 to 400 nM against either a constant concentration of TRF1 TRFH (0.5 M in FP buffer) or FP buffer alone (25 mM HEPES-NaOH pH 7.5, 100 mM NaCl, 1 mM TCEP, 0.05% w/v CHAPS)