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Class 1 ferroptosis inducers, including erastin, imidazole ketone erastin, sulfasalazine, sorafenib, and HG106, directly inhibit xCT activity [92,93] and induce ferroptosis by preventing cystine uptake and depleting cysteine or GSH, thereby inducing lipid peroxidation and cell death [15,49]

Poria aqueous extract improves metabolic homeostasis and inflammation by restoring intestinal homeostasis, controlling the relationship between GM and host metabolites, modulating hypothalamic neurotransmitters, decreasing proinflammatory cytokines, and inhibiting the expression of TNF-/NF-B signaling pathway proteins

Biomaterials 185:322332

The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

The reaction was allowed to proceed at 37 C for 2 h or for the indicated times

& Forman, H