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In rabbits fed a 0.5% high-cholesterol diet, VEGF receptor-2 decreased in the CC, while VEGF increased initially but declined later [132], another study by Ryu et al also showed that in rats on a 4% high-cholesterol diet for 3 months, VEGF and VEGF receptor-2 were downregulated in the CC [133]

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According to existing studies and expert opinions, we offered a comprehensive and updated overview of feasible approaches for the diagnosis and management of siLNs (summarized in Figure 5 )

Similarly, the average area of lipid droplets in granulosa cells decreases with age