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In addition, most of the effective analgesics in NP failed to provide symptomatic relief of CIPN and often exhibit side effects (Han and Smith, In general, unlike other types of NP (including those induced by trauma and diabetes) axonal degeneration in peripheral nerves is not present in CIPN (Ji et al., Regarding to CIPN induced by the taxanes, Duggett et al

Solvent accessibility into the primary binding site is unhindered by the F319, which remains splayed open thereby retaining dDAT in an outward-open conformation (Fig

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Taken together, these findings suggest that serotonergic hypoactivity alone does not fully account for the complex pathophysiology of MDD

Low baseline platelets