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ROS are highly reactive molecules that can damage cellular components such as proteins, lipids and DNA, resulting in a range of health issues

Considering the converging roles of the GSK3SIRT7 axis in oncogenic and energetic stresses, combining ERK inhibition might mitigate the impairment of SIRT7 phosphorylation by IF-elicited energy stress

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To increase accumulation in the posterior segment after topical administration, we previously developed a novel hypotonic in situ gel-forming eye drop formulation [20]