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NADPH levels decreased to 69% of their initial concentration, a loss of 0.74 M (Supplementary Figure 1a-f)

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Future research should focus on establishing a longitudinal sampling framework encompassing multiple time points, multiple pathways, and multiple body-fluid sources together with development of dynamic predictive biomarkers using liquid-biopsy platforms such as exosomal miRNA, cell-free DNA, and metabolomic signals

doi: 10.3389/fendo.2022.945578 Received 16 May 2022 Accepted 05 October 2022 Published 20 October 2022 Volume 13 - 2022 Edited by Tiziano Baroni, University of Perugia, Italy Reviewed by Sahar Houshdaran, University of California, San Francisco, United States