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It reduces memory loss in the intracerebroventricular administered streptozotocin-induced memory decline in SpragueDawley rats (Naik et al., 2017) and mediates neuroprotection against oxidative toxicity via the estrogen receptor signaling pathway in human neuronal SH-SY5Y cells (Song et al., 2015)

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131 In addition, molecular analysis of esophageal biopsies procured from participants in this trial showed that IL-13 neutralization markedly corrected the EoE transcriptome, as there was altered expression of genes in several pathways known to be dysregulated in EoE, including eosinophil recruitment, mastocytosis, tissue fibrosis, and epithelial barrier function

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Overall, the study demonstrates that functional group chemistry directly governs the structural and purification performance of GO-based membranes