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1422-C IMPACT OF LONG-TERM TREATMENT WITH CONTINUOUS TENOFOVIR ALAFENAMIDE (TAF) OR AFTER SWITCH FROM TENOFOVIR DISOPROXIL FUMARATE (TDF) ON HEPATOCELLULAR CARCINOMA (HCC) INCIDENCE IN PATIENTS WITH CHRONIC HEPATITIS B (CHB) Young-Suk Lim 1 , Grace Lai-Hung C Wong 2 , Sang Hoon Ahn 3 , Wai-Kay Seto 4 , Kosh Agarwal 5 , Harry L

Empty pTRV2 vector was used as a control

Early increases in the HIF-1 target phosphoglucomutase 1 (PGM1) in seal cells may regulate glucose metabolism during hypoxia, consistent with glycolytic repression via ZBTB7A transcriptional control [73, 74]