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In conclusion, the observation of dysregulated iron homeostasis, increase in labile iron, and excessive lipid peroxidation in lesions and CSF of MS patients put forward ferroptosis as an important detrimental factor in MS disease

After administration, the hydrogel displays lens-like adhesion to corneal defects and establishes a localized drug depot, which effectively inhibits corneal fibrosis and scar formation of fungal keratitis (164)

Pharmacogenomics 5 : 11511162 Worzalla JF, Shih C, Schultz RM (1998) Role of folic acid in modulating the toxicity and efficacy of the multitargeted antifolate, LY231514

10.1371/journal.pone.0161091 PLoS One 31 LeungT

Myoglobin toxicity in proximal human kidney cells: roles of Fe, Ca 2+ , H 2 O 2 , and terminal mitochondrial electron transport

Evidence suggests that farnesyl residues from the cholesterol biosynthetic pathway play a critical role in the activation of the G proteins and Ras p21 oncoprotein ( ras gene in several types of cancer