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Selenium, selenoproteins, and immunity

doi: 10.1016/j.jtemb.2006.10.001 17 DanksD

Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors

Taking these observations further, epidermal-specific (K14-cre mediated) ER null mice were shown to phenocopy global ER nulls, and the ER agonist DPN was shown to directly promote keratinocyte migration in vitro, suggesting a key role for epidermal ER [128]