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Here are some common tests for chronic fatigue and autoimmunity: Autoimmune Markers: ANA (antinuclear antibodies) for lupus RF (rheumatoid factor) and anti-CCP for rheumatoid arthritis TPO and TG antibodies for Hashimotos or Graves disease Inflammatory Markers: CRP (C-reactive protein) ESR (erythrocyte sedimentation rate) Thyroid Function Tests: TSH, Free T3, Free T4 Reverse T3 (to assess thyroid conversion issues) Mitochondrial and Nutrient Testing: Organic acid tests (to check for mitochondrial dysfunction) B12, and magnesium levels Gut and Food Sensitivity Testing: Comprehensive stool analysis Zonulin (to assess leaky gut) IgG food sensitivity testing By identifying underlying fatigue triggersbe it autoimmune activity, nutrient deficiencies, or gut dysfunctiona more targeted treatment approach can be taken

L.RamkumarM

J.ArmstrongJ

The pathophysiology of AD is intricate, involving abnormal phosphorylation of Tau protein, neuroinflammation, mitochondrial dysfunction, ferroptosis, and damage to cholinergic neurons

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Key pathways discussed include the RTK, EGFR, and RAS metabolic dependency pathways, as well as metabolic abnormalities arising from IDH mutations