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The PPP is the primary cellular source of NADPH, which supports reductive biosynthesis, antioxidant defense, and endothelial nitric oxide synthase (eNOS)-mediated nitric oxide (NO) production [62]

Disclosures: Jae Seung Lee: Nothing to Disclose, Sung Won Lee: Nothing to Disclose, Sang Gyune Kim: Nothing to Disclose, Yeon Seok Seo: Nothing to Disclose, Su Jong Yu: Nothing to Disclose, Hyung Joon Yim: Nothing to Disclose, Hye Won Lee: Nothing to Disclose, Mi Na Kim: Nothing to Disclose, Beom Kyung Kim: Nothing to Disclose, Jun Yong Park: Nothing to Disclose, Do Young Kim: Nothing to Disclose, Sang Hoon Ahn: Nothing to Disclose, Seung Up Kim: Nothing to Disclose 407 FUNCTIONAL ANALYSIS OF FUMARYLACETOACETATE HYDROLASE AS A HEPATOCYTE HOST FACTOR GENE REGULATING HEPATITIS B VIRUS REPLICATION AND HEPATOCARCINOGENESIS Shouichi Namikawa 1 Takuto Nosaka 1 Yosuke Murata 1 Tomoko Tanaka 1 Yu Akazawa 1 Kazuto Takahashi 1 Tatsushi Naito 1 Masahiro Ohtani 1 Yasunari Nakamoto 1 , 1 University of Fukui Background: Recent molecular biological analyses have highlighted the importance of host factors in anti-viral and/or anti-tumor effects

Using antibodies specific for phosphorylation at Ser12, it was found that TCR stimulation induces DRAK2 Ser12 autophosphorylation ( 2+ into T cells

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Certain drugs are inactivated so efficiently upon their first pass through the liver that they cannot be administered orally and must be given parenterally