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[147] Additionally, zebrafish may exhibit AD-like cognitive and behavioral manifestations that can be further explored in drug screening to identify potential treatments for AD [150, 151]

4428-A PFOA EXPOSURE RESULTS IN SEX-DEPENDENT EFFECTS ON HEPATIC AND WHOLE-BODY LIPID HOMEOSTASIS THAT DIFFER BY PPARA STATUS Frederick Ekuban 1 , Greylin Nielsen 2 , Dibson Dibe Gondim 1 , Wendy Heiger-Bernays 2 , Thomas Webster 2 , Matthew Cave 1,3 and Jennifer Schlezinger 2 , (1)University of Louisville, Louisville, KY, (2)Boston University, (3)Robley Rex VAMC Background: Per- and polyfluoroalkyl substances (PFAS) are a large group of persistent chemicals that have been released pervasively in the environment leading to widespread exposure for human populations

However, the diversity and heterogeneity of the research population must be considered, such as age, gender, ethnicity and any comorbidities