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Endpoint Assays for Mechanistic Insights The choice of assay depends on the specific pathway being investigated: Hormone Secretion: The amount of growth hormone released into the cell culture medium is quantified using a species-specific ELISA (Enzyme-Linked Immunosorbent Assay) kit

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

Genes associated with lipid metabolism, such as synaptojanin1 ( SYNJ1 ) (180, 181), are linked to PD risk and show altered lipid profiles or functions in models