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Safety and side effects affect compliance

This is especially true for high-performing professionals, parents, and students trying to juggle mental focus and physical stamina

Insulin normally suppresses gluconeogenesis while promoting lipogenesis, however, under insulin resistant states such as T2D, hepatic lipogenesis remains insulin sensitive and suppression of gluconeogenesis is insulin resistant, leading to a metabolic state called selective hepatic insulin resistance (199)

These indicate either excessive dosing or sensitivity to the peptide

Thermal stress causes hydrolysis of the acylated side chain, rendering the peptide useless

Hydrochloric acid and/or sodium hydroxide may have been added during manufacture to adjust the pH (range 4.5-7.0)