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The best binding was observed for the histidine containing peptide as expected, whereas slightly weaker affinity was observed for amide (Q, N) or amine (K) containing side chain, whereas carboxy (D,E), thioether (M) or aromatic (F,Y,W) functional groups hardly enhanced affinity compared to the single histidine containing peptide (Fig

An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer

For example, during the biosynthesis of dapdiamide E, at least three separate enzymatic transformations are sandwiched between the first amide bond formation catalyzed by DdaG (ABS) and the second amide bond formation catalyzed by DdaF (ATP-grasp enzyme) 40,41 (Supplementary Fig

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Such an rapid migration is also supported by the observation that S

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