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* Correspondence: Syed Arman Rabbani, [email protected] Parvez, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The delay in onset of symptoms after exercise in ME/CFS may correspond to the time frame needed for pro-inflammatory signals to (a) reach the brain and trigger a stress response, and then (b) induce glial reactivity (to which DAMP, inflammasomes and signals from the hypothalamus-pituitary-adrenal axis could contribute) (Fleshner et al., 2017)

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97 The research team led by Zheng Wang demonstrated that silencing STUB1 reduces NRF2 ubiquitination, thereby promoting macrophage differentiation into the M2 type and inhibiting the progression of OA