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Interestingly, we did not observe any significant variations in MMA concentration in non-CNS tissues of adult male and female Tbx1 +/ mice (Fig S2), indicating that this phenotype is brain-specific

Mar-Apr 2007;11(2):119-24

These differences are likely to reflect monovalent binding of Fab compared with divalent binding of whole IgG, depending upon the spacing of targeted epitopes on the virion surface 94,95,96