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For example, improved blood flow can lead to a 20% increase in oxygen delivery to tissues [1] [4] [6]

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This model better accounts for cases that deviate from the canonical Braak pattern and underscores the multifactorial etiology of PD [82]

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It limits the duration of Wnt signaling

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Therefore, understanding the mtDNA-mediated neuroinflammation is crucial to develop targeted therapies for NDDs and the aging brain

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