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C4 Therapeutics, Kymera, Nurix Therapeutics, Accutar Biotech are examples of other sponsors with cereblon-based PROTACs in clinical trials, most of which are at an early stage of clinical development (phase I) and therefore clinical results from these trials are still scarce

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the full search strategy is detailed in Supplementary Table S1

3, severe damage

A systematic review and meta-analysis of observational studies

They can be constructed by using a wide range of substrates including organic (e.g., liposomes, micelles, hydrogels, etc.), 17,18,19 inorganic (e.g., metal/metal oxide particles, silica nanoparticles, quantum dots, etc.), 20,21 and biomass-derived materials (e.g., exosomes, cells, bacteria, etc.)