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Withdrawal rates due to adverse effects serve as a practical measure of real-world tolerability, making this finding especially relevant for clinical application

Early intervention, ideally concurrent with chemotherapy rather than after nerve damage has become established, may provide better outcomes than delayed treatment

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Exposure to toxins: Pesticides, heavy metals, pollution, household chemicals, and cigarette smoke overwhelm the detox system, which can cause glutathione deficiency

Excessive swelling of nerve roots: Important factor for recurring sciatica after lumbar surgery