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While we are not aware of any contra-indications for pregnant or nursing women, Radiance requires written consent from a primary care provider or OB/GYN for patients who are pregnant and/or nursing

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Cochrane Database of Systemic Reviews 2016, Issue 2

Preclinical research indicates that NNMT inhibition may influence adipose tissue function, mitochondrial efficiency, and intracellular energy utilization through mechanisms distinct from traditional endocrine or appetite-regulating pathways

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Importantly, these effects occur without changes in food intake, indicating metabolic rather than anorectic mechanisms