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Additionally, ligand-trap agents such as luspatercept (TGF-/activin inhibition, facilitating late-stage erythroid differentiation) (Santini and Consagra, 2025), BRAF inhibitors that treat anemia through activation of MAPK signaling (Wu et al., 2024), and low-cost host-defense peptides with anti-inflammatory properties (e.g., IDR-1018) ( Figure 1 Statements Author contributions F-FL: Investigation, Writing original draft