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Fontana L, Klein S, Holloszy JO, Premachandra BN

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Hydrazine-containing functional groups have been associated with hepatotoxicity and possible genotoxicity ( Hydralazine is a direct arteriole vasodilator with several critical indications: it is a primary intravenous option for hypertensive emergencies and severe pregnancy-related hypertension (as it effectively maintains blood flow to the uterus and fetus), a secondary option for resistant hypertension, and, when combined with isosorbide dinitrate, a mortality-reducing adjunctive therapy for severe heart failure (HFrEF), particularly in African-American patients