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Several studies have found that chronic ethanol treatment causes decreased methylation of the DAT1 promoter, resulting in the upregulation of DAT in a variety of brain regions (5456)

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Epigenetic mechanisms such as DNA methylation and altered expression of mRNA and short and long non-coding RNAs such as microRNAs (miRNAs) are emerging as key mediators of the relationship between early environmental adversity and brain development and function