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doi: 10.3389/fncel.2025.1669272 Received 19 July 2025 Revised 10 December 2025 Accepted 12 December 2025 Published 17 February 2026 Volume 19 - 2025 Edited by Luca Raiteri, University of Genoa, Italy Reviewed by Cataldo Arcuri, University of Perugia, Italy Updates Copyright 2026 Uemura, Hiro, Attachaipanich, Du, Yusof, Kinoshita, Hikosaka and Ohtsuki

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First, the period covered by the studies is more than thirty years, a period which has seen a considerable change in the diagnostic criteria, a variation in the test measures used, and a significant development of the methodology for AD and MCI investigation

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