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Additionally, ROS can promote endothelial fibrosis, resulting in downregulation of adhesion proteins, thereby compromising endothelial integrity and increasing permeability (48)

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This treatment reversed neuronal deficits, improved motor function, and prevented the STZ-induced loss of skeletal muscle[52]

Future research should prioritize the identification of actionable targets within the ferroptotic pathway, assess the regulatory potential of natural compounds and traditional medicines on iron metabolism, and accelerate translational efforts to incorporate ferroptosis-modulating strategies into clinical practice (Table 1)

10.1002/cpt1971122part2397 101 KarakidaF.IkeyaY.TsunakawaM.YamaguchiT.IkarashiY.TakedaS.et al (2007)