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Description

Front Neurol 14:1046910

The reduction of human RNR, which was suggested to follow mechanism (ii) 46 , therefore needs to be analyzed and monothiol mechanism (iii) should be also considered

The accepted mechanism of this catalytic reaction (derived from many years of biochemical and modelling studies) envisages a two-step process shown in Equations 2 and 3 [Alfonso-Prieto, 2008]