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As a specific substrate of GPX4, RSL3 can bind to GPX4 and inactivate it, induce the accumulation of lipid ROS and lead to ferroptosis

doi: 10.3354/cr01074 94 evkovH.MakovP.TarkowskD.MaekT.LipavskH

By contrast, genes such as RsGSTZ1 and RsTCHQD1 showed decreased expression from S3 to S4, indicating that their functions may be confined to earlier stages of flower development

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Activated DCs can mediate effector T cell recruitment to the kidney, contributing to tubulointerstitial inflammation and potentially driving acute injury or chronic glomerulonephritis [17]

Hsu CG, Chvez CL, Zhang C, Sowden M, Yan C, Berk BC