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A 2023 review in Frontiers in Physiology noted that mitochondrial-derived peptides like MOTS-c represent a functionally separate class from growth-hormone-axis compounds such as Tesamorelin underscoring why comparison, rather than substitution, is the right framework for evaluating them

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Flow cytometry showed that the cells were positive for mesenchymal markers CD13, CD29, CD44, CD73, CD90, and CD105, while they were negative for hematopoietic markers CD14, CD34, and CD45

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Forsyth JC, Mueller PD, Becker ChE, Osterloh J, Benowitz NL, Rumack BH, Hall AH

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