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276 Interestingly, accumulation of the BNIP3 paralog BNIP3L/NIX protein not only triggers mitophagy but also activates the mTORC1 pathway

In ARDS patients, macrophages secrete CXCL8 (IL-8) to activate a circulating neutrophil recruitment cascade via C-X-C chemokine receptor 1 (CXCR1) receptors

We next assessed if alkyne-HNE can bind to NLRP3 by treating THP-1 macrophages with 3 M HNE or 10 M alkyne-HNE after inflammasome activation by nigericin

10.1038/nm747 5 AyalaA.MuozM

Gene-level read counts were obtained using featureCounts (v1.5.0-p3), and expression levels were normalized as FPKM values