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In an oncogenic context, the IGF family regulates a number of biological processes such as cancer cell proliferation, apoptosis, metabolism and protein synthesis, which are closely associated with the activation of PI3K/AKT signaling, which subsequently promotes the transcription of downstream pro-oncogenic target genes such as c-Myc and HIF-1 (77)

The most recent meta-analysis identified that the relationship between Se and type 2 diabetes mellitus differs between observational studies and randomised controlled trials

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Monitoring of fasting glucose and HbA1c every 12 weeks during a research cycle is standard

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Melatonin use to mitigate the nephrotoxicity of drugsAnticancerCisplatin Cisplatin, cis-diamminedichloroplatinum II, is broadly and effectively used antineoplastic agent in chemotherapy of most solid tumors