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A phase 3 double-blind, double-dummy, randomised controlled trial (RCT) comparing IPX203 with immediate-release (IR) LD/CD showed a statistically significantly greater increase in daily ON-time of + 0.53 h, and this difference was achieved with a mean of 3 daily doses vs 5 in the IR LD/CD arm [22]

Iron homeostasis is critical for cellular survival, and dysregulation of iron metabolism proteins by endogenous Exos can drive ferroptosis [100]

The primary outcome was disease burden, assessed using the measure disability-adjusted life years (DALYs), with age weighting and discounting in untreated and DAA-treated groups

Instead, they increased from the IH1 to IH3 groups and then decreased gradually in IH4 and IH5 groups

Lavrynenko O, Titz B, Dijon S, Santos DD, Nury C, Schneider T, et al