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This work was partially supported by the National Natural Science Foundation (31770796 to Y.J., 81730099 to X.X.), the National Science and Technology Major Project (2018ZX09711002-002-002) to Y.J., the National Key R&D Programs of China (2018YFA0507002), the Shanghai Municipal Science and Technology Major Project (2019SHZDZX02), the CAS Strategic Priority Research Program (XDB37030103) to H.E.X., and the Shanghai Municipal Science and Technology Commission Grant (20S11903200) to X.X

S -dichlorovinyl, such as N -acetyl- S -(1,2-dichlorvinyl)-L-cysteine and S -(1,2-dichlorovinyl)-L-cysteine, induce toxicity towards the cells responsible for their production (Spencer and Schaumburg, 1985

Epilepsia 53 , e204e207 (2012)

Available online at: 9 WeykerPDWebbCAKiamaneshDFlynnBC

This forceful change in metabolism could be due to the deficiency of succinyl-CoA, which is a consequence of VitB12 deficiency, although no substantial data exists (Figure 4B)

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