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Notably, NAFLD frequently precedes and serves as a stronger predictor of conditions such as obesity, type 2 diabetes mellitus, hyperlipidemia, hypertension, and cardiovascular disease

If culprit medications remain clinically indicated, prescribers should use the lowest possible dose, a safer alternative with fewer adverse effects, or non-pharmacologic therapy, rather than initiating a cascade medication to address the ADE

In skeletal and cardiac muscle, fatty acids are the main substrate for energy production

Collectively, these findings highlight the lineage-specific functional consequences of TCA-cycle perturbation in the intestinal epithelium