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However, evidence regarding their systemic metabolic effects in children, particularly from non-Western populations, remains limited

Symptomatology (i.e., paresthesia, spontaneous pain, tactile allodynia and mechanical and thermal hypo/hyperalgesia) may improve and resolve spontaneously, or culminate in total loss of sensation and ultimately in foot ulceration and amputation

Moving forward, the integration of cutting-edge technologies such as multi-omics approaches, advanced imaging techniques, and computational modeling will be pivotal in unraveling these complexities