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Activation of SIRT1 improves insulin sensitivity and regulates blood glucose level: SIRT1 can directly deacetylate and activate peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), thereby promoting mitochondrial biogenesis and enhancing cellular energy efficiency, which in turn strengthens tissue responsiveness to insulin [107]

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59 mtDNA-encoded proteins are mainly involved in the respiratory chain and are therefore key components of cellular energy production

10.1002/ps.6035 49 JingL.ZhuangF.FengW.HuangH.ChenY.HuangB

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