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The median (range) ChildPugh scores for subjects in the mild and moderate hepatic impairment groups were 5 (56) and 7 (78), respectively

Furthermore, long-term oral treatment of AC augmented the ATP/ADP ratio, which in turn diminished the quantity of reactive oxygen species (ROS) and enhanced the cellular oxidative stress response

In vitro research shows that quercetin is a strong non-competitive inhibitor of OAT1, with half-maximal inhibitory concentration (IC50) values less than 10 mcM

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Isaacson JS, Scanziani M

Given that AKG exerts similar effects on both cumulus cells and oocytes, we hypothesized that AKG influences NADPH and GSH production in cumulus cells, subsequently transporting them to oocytes via gap junctions