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Cocaine Cocaine has potent stimulant properties that contribute to its highly addictive potential [282] and its use during pregnancy has been linked to adverse outcomes including low birth weight, prematurity [328], IUGR, and miscarriage [273, 329, 330]

Imbalances within the microbial community can either positively or negatively affect the integration of the gut and skin ( Supplementary Figure 1A )

It has been reported that supplementation with -KG can reverse intestinal stemness and Wnt hyperactivation induced by low glutamine [19]

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Studies indicate that the prevalence of four principal microbial phylaFirmicutes, Actinobacteria, Bacteroidetes, and Proteobacteriacorrelates with host bone mass (72)utilizing 16S rRNA sequencing demonstrated disparities in the GM between OP patients with osteoporotic fractures and healthy controls

It is important to understand not only the direct effect of NPs on the foetus, but also the indirect effects mediated by circulating cytokines or other secondary messengers generated from oxidative stress and pulmonary inflammation in the maternal lungs [198,199,200,201,202] [174], placental dysfunction [199], or genotoxicity [203, 204]