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Similar to folate, multivariable RCS models showed a significant nonlinear correlation between serum vitamin B12 concentrations and all-cause mortality ( P for nonlinear =0.016), with the risk of mortality decreasing with increasing vitamin B12 levels when serum vitamin B12 concentrations were below the median value, reaching a nadir risk at around 457 pg/mL

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Macrophages were also found to be required for angiogenesis in xenografts secreting VEGFA or overexpressing zebrafish VEGFAA, suggesting that zebrafish macrophages enhance VEGFA-driven tumor angiogenesis

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Interestingly, eliminating phase separationby either mutating the acidic-type TAD or substituting basic residues in the DNA-binding motifbarely impairs PIF4s ability to restore warm temperature-induced hypocotyl elongation in the pif4 mutant