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2020;6:e19

stimulated macrophage cell activation, leading to the upregulating of pro-inflammatory cytokines, including TNF-, IL-6, and IL-10

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Catheter Cardiovasc Interv

Moreover, non-targeted effects such as the abscopal (RIAE) and bystander effects (RIBE) can induce biological consequences, such as adaptive response, genomic instability and genetic susceptibility, to neighboring cells through signaling factors released by irradiated cells [124, 125]

The enhanced permeability and retention (EPR) effect allows passive targeting of tumor tissues, leading to improved therapeutic efficacy